Hongli Wang

Dynamic mechanisms of time-of-day-dependent adaptive immunity and vaccination responses

This paper uses mathematical modeling to show that bistability in dendritic cell homing, regulated by the circadian clock, explains time-of-day-dependent immune responses to vaccines.

A kinetic model for USP14 regulated substrate degradation in 26S proteasome

The paper develops a kinetic model to describe USP14-regulated substrate degradation in the 26S proteasome, showing that USP14 reduces degradation rates and depends on substrate and ATP concentrations.

Modeling liquid-liquid phase separation and its impact on proteasomal substrate degradation

This study develops a reaction-diffusion model to quantify proteasome-associated liquid-liquid phase separation and its bidirectional impact on degradation efficiency.