Qi Ouyang

SparseSeg improves cryo-vEM segmentation with sparse annotations by using exemplar-driven propagation and multi-kernel U-Net for accurate, context-aware organelle detection.

This paper uses mathematical modeling to show that bistability in dendritic cell homing, regulated by the circadian clock, explains time-of-day-dependent immune responses to vaccines.

The paper develops a kinetic model to describe USP14-regulated substrate degradation in the 26S proteasome, showing that USP14 reduces degradation rates and depends on substrate and ATP concentrations.

This study uses molecular dynamics simulations to show that specific THz frequencies enhance conductance of Kv1.2 and Nav1.5 ion channels by affecting ion motion in selectivity filters.

The paper outlines a simulation protocol to identify THz frequencies affecting ion channels and finds a broad frequency band between 1 to 20 THz impacts CaV channels.

The paper investigates subunit shuffling dynamics in KaiC's central hub, revealing how ATPase activity regulates this process in the cyanobacterial circadian clock.

This study develops a reaction-diffusion model to quantify proteasome-associated liquid-liquid phase separation and its bidirectional impact on degradation efficiency.

The paper investigates how ZFAND5 activates the 26S proteasome by inducing conformational changes that enhance substrate degradation.

This study shows that breaking DNA-cell size scaling in E. coli leads to a linear growth regime and resource reallocation to plasmid-borne gene expression.

The paper shows that yeast cells under glucose-limitation need more response cost for osmostress defense, even with unchanged growth rates.

The paper constructs a thermodynamically realistic model of the fission yeast G2/M transition, showing that phosphorylation energy controls Cdc2 activation dynamics and bistability.