Author

Pascal Mutz

National Institutes of HealthORCID 0000-0002-0430-2095Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:metagenomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Research Focus:phylogenetics / evolution· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

Eugene V. KooniniD· 5 shared Mart KrupovìčiD· 4 shared Yuri I. WolfiD· 3 shared Natalya YutiniD· 2 shared Valerian V. DoljaiD· 2 shared Akihito FukudomeiD· 1 shared Anamarija ButkovićiD· 1 shared Anastasia A. GulyaevaiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersMicrobiology

Eugene V. KooninORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Diversity and evolution of the ribovirian class Stelpaviricetes

Anastasia A. Gulyaeva, Pascal Mutz, Qiyan Liu, Yuri I. Wolf, Guan‐Zhu Han, Eugene V. Koonin, Valerian V. Dolja

This study identifies 103 putative families within the Stelpaviricetes class of ribovirians, revealing their evolutionary relationships and suggesting a protist origin for the class and fungal origin for Potyviridae.

bioRxiv · Aug 4, 2026 · PreprintMicrobiology

Identification of Obelisk-like covalently closed circular RNA replicon in hot springs by double-stranded RNA sequencing and expansion of the diversity of the Obelisk superfamily

Syun‐ichi Urayama, Akihito Fukudome, Pascal Mutz, Yosuke Matsushita, Yoshihiro Takaki, Yosuke Nishimura, Sofia Medvedeva, Mart Krupovìč, Eugene V. Koonin, Takuro Nunoura

The paper identifies a new family of Obelisk-like cccRNAs in hot springs using FLDS, expanding the Obelisk superfamily with structurally similar but sequence-divergent proteins.

bioRxiv · Sep 3, 2025 · PreprintMicrobiology

The protein structurome of Orthornavirae and its dark matter

Pascal Mutz, Antônio Pedro Camargo, Harutyun Sahakyan, Uri Neri, Anamarija Butković, Yuri I. Wolf, Mart Krupovìč, Valerian V. Dolja, Eugene V. Koonin

The paper uses protein structure prediction to analyze dark matter proteins in Orthornavirae, identifying new domains and highlighting the prevalence of disordered regions.

mBio · Dec 23, 2024Peer-reviewedEvolutionary Biology

Jumping DNA polymerases in bacteriophages

Natalya Yutin, Igor Tolstoy, Pascal Mutz, Yuri I. Wolf, Mart Krupovìč, Eugene V. Koonin

The paper identifies instances of DNA polymerase (DNAP) swapping among bacteriophages, showing gene replacements between families and subfamilies without altering surrounding gene organization.

Virology Journal · Aug 26, 2024Peer-reviewedMicrobiology

Mriyaviruses: Small Relatives of Giant Viruses

Natalya Yutin, Pascal Mutz, Mart Krupovìč, Eugene V. Koonin

The paper identifies a new class of viruses, Mriyaviricetes, with small genomes related to giant Nucleocytoviricota viruses, suggesting they are close relatives of their ancestors and use a unique rolling circle replication mechanism.

mBio · Jun 4, 2024Peer-reviewedMicrobiology