Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability
Takumi Taketomi, Takunori Yasuda, Rikuri Morita, Jae Hyun Kim, Yasuteru Shigeta, Çağla Eroğlu, Ryuhei Harada, Fuminori Tsuruta
This study shows that an ASD-associated mutation in SPARCL1 impairs Hevin secretion by causing ER stress through structural instability.
Scientific Reports · Jul 13, 2022Peer-reviewedMolecular Biology