Çağla Eroğlu

An astrocytic AMPAR-dependent parity signal preserves synaptic strength

The paper shows that astrocytic AMPAR inhibition in mouse striatal projection neurons converts glutamatergic activity into long-term depression, suggesting astrocytic glutamate sensing stabilizes synaptic strength.

δ-catenin controls layer-specific transcriptional maturation of astrocytes via Zbtb20

This study shows that δ-catenin regulates astrocyte transcriptional maturation and circuit stabilization via Zbtb20, with loss of δ-catenin disrupting layer-specific astrocyte identities and prolonging ocular dominance plasticity.

Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.

This study identifies Nedd4l-mediated ubiquitination of NL2 as essential for astrocyte morphogenesis during development.

Reprogramming of neuronal genome function and phenotype by astrocytes

This paper shows that astrocytes reprogram neuronal gene expression and chromatin accessibility, affecting thousands of genes and regulatory elements, including those linked to schizophrenia and Alzheimer's disease.

Phosphatidylserine exposure by developing astrocytes initiates microglia-mediated developmental cell death

The paper shows that phosphatidylserine exposure by developing astrocytes triggers microglia-mediated cell death, leading to vascular defects in the retina and cerebral cortex.

Elucidating an anterior cingulate circuit for self-initiated actions and rescue of Parkinsonian akinesia

This study identifies a cortical circuit involving ACC-D1+ neurons critical for initiating goal-directed movements and shows its therapeutic potential in Parkinsonian akinesia.

Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling

This study shows microglia instruct astrocyte-synapse interactions via Wnt signaling, enabling microglia to remove synapses during activity-dependent remodeling.

Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex

This study shows that mitochondrial fission is essential for astrocyte morphogenesis and organization in the cortex, with Drp1 loss causing morphological and functional deficits.

SynBot: An open-source image analysis software for automated quantification of synapses

SynBot is an open-source software for automated synapse quantification from light microscopy images, improving speed, reproducibility, and ease of use.

Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function

This study identifies Neurocan as an astrocyte-secreted protein that promotes inhibitory synapse formation and function through its C-terminal fragment.

Astrocytic thrombospondins 1 and 2 are required for cortical synapse development controlling instrumental performance

This study shows that TSP1 and TSP2 from astrocytes are essential for synapse development and effort control during operant conditioning in mice.

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

This study shows that the LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance by hyperphosphorylating ERM proteins, which disrupts the Ezrin/Atg7 interaction and autophagy.

GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes

The paper introduces GEARBOCS, an AAV-based CRISPR/Cas9 tool for in vivo astrocyte gene editing, demonstrating its utility for knockout, tagging, and reporter knock-in strategies in mice.

Prenatal Environmental Stressors Impair Postnatal Microglia Function and Adult Behavior in Males

This study shows that prenatal exposure to environmental toxins and stress impairs microglial function and leads to behavioral issues in male mice.

Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability

This study shows that an ASD-associated mutation in SPARCL1 impairs Hevin secretion by causing ER stress through structural instability.

Sparcl1/Hevin drives inflammatory and neuropathic pain through astrocyte and NMDA receptor signaling

This study shows hevin, an astrocyte-secreted protein, maintains chronic pain through NMDA receptor signaling, and neutralizing hevin may offer new therapeutic strategies for pain and neurodegeneration.

Training-Induced Circuit-Specific Excitatory Synaptogenesis is Required for Effort Control

This study shows that training-induced excitatory synaptogenesis in the ACC->DMS circuit is required for effort control, not learning, and is mediated by the 2{delta}-1 protein.

Developmental onset of enduring long-term potentiation in mouse hippocampus

This study examines the developmental timeline of long-term potentiation (LTP) in mouse hippocampus, revealing species differences in the onset and reliability of synaptic plasticity.

Thrombospondin-1 Promotes Circuit-Specific Synapse Formation via β1-Integrin

This study shows that Thrombospondin-1 promotes circuit-specific synapse formation in direction-selective retinal ganglion cells via β1-integrin.