Enhanced thermal stability enables human mismatch-specific thymine-DNA glycosylase to catalyse futile DNA repair
Diana Manapkyzy, Botagoz Joldybayeva, Alexander A. Ishchenko, Bakhyt T. Matkarimov, Dmitry O. Zharkov, Sabira Taipakova, Murat K. Saparbaev
This study shows that full-length TDG, but not its catalytic domain or MBD4, can excise T and C from undamaged DNA under specific conditions, suggesting a role in futile DNA repair.
PLoS ONE · Oct 18, 2024Peer-reviewedBiochemistry