BioinformaticsCommunications ChemistryPeer-reviewed
A Folding-Docking-Affinity framework for protein-ligand binding affinity prediction
Ming-Hsiu Wu, Ziqian Xie, Degui Zhi
This study introduces a framework that predicts protein-ligand binding affinity by folding proteins, determining binding conformations, and using 3D structures, achieving performance comparable to existing docking-free methods.
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