Structural Dynamics of the Dengue Virus Non-structural 5 (NS5) Interactions with Promoter Stem Loop A (SLA)
Juliet O. Obi, Kyle C. Kihn, Linfah McQueen, James K. Fields, Greg A. Snyder, Daniel Joseph Deredge
This study investigates the structural dynamics of DENV2 NS5 interacting with SLA using SPR, HDX-MS, computational modeling, and cryoEM, revealing conformational changes and a conserved binding mode.
npj Viruses · Apr 16, 2025Peer-reviewedBiophysics