The cyclic nucleotide binding sites of Swiss-Cheese, the Drosophila orthologue of human PNPLA6, are required for its catalytic function
Alexander D. Law, Jill S. Wentzell, Alexandre Bettencourt da Cruz, Luke C. Marney, Doris Kretzschmar
The paper investigates the role of cyclic nucleotide binding sites in the Drosophila protein SWS, showing that mutations in these sites affect its catalytic function and phospholipase activity.
bioRxiv · Dec 13, 2025 · PreprintNeuroscience