NeurosciencebioRxivPreprint
Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease
Joseph R. Herdy, Emma E Taylor, Lukas Karbacher…·Fred H. Gage
This study identifies LINE-1 retrotransposons as drivers of neuronal senescence in Alzheimer's disease through cytoplasmic DNA sensing and the cGAS-STING pathway.
DOI 10.64898/2026.07.27.740588