Author
Ionis Pharmaceuticals (United States)ORCID 0000-0001-6134-1165Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
E Sitarska, Anand Saminathan, Gustavo Scanavachi…·Tomas L. Kirchhausen
This study tracks antisense oligonucleotides (ASOs) through endocytic trafficking, finding that productive escape occurs early in endosomes before sequestration in late compartments.
Judith Praena Fernandez, Annette Gärtner, Jesús Pérez‐Pérez…·Paolo Beuzer
The paper develops URSA, a method to quantify DNA repair activity at the CAG repeat tract in HD, showing it correlates with somatic instability and can be measured rapidly in blood cells.
Joseph R. Herdy, Emma E Taylor, Lukas Karbacher…·Fred H. Gage
This study identifies LINE-1 retrotransposons as drivers of neuronal senescence in Alzheimer's disease through cytoplasmic DNA sensing and the cGAS-STING pathway.
Dylan A. Reid, Patrick Reed, Johannes C. M. Schlachetzki…·Fred H. Gage
The paper identifies DNA repair hotspots in post-mitotic human neurons linked to genes essential for their identity and function.
Keria Bermudez‐Hernandez, Sarah Keegan, Donna R. Whelan…·David Fenyö
The paper introduces a method to quantify molecular interactions using stochastic modeling and super-resolution microscopy, validated with simulated and experimental data.