Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implication for microglia activation and sex differences
Maitry Ronakbhai Trivedi, Amogh Manoj Joshi, Jay Shah, Benjamin P. Readhead, Melissa A. Wilson, Yi Su, Eric M. Reiman, Teresa Wu, Qi Wang
This paper uses an interpretable deep learning framework to analyze transcriptomic data from Alzheimer's disease brain tissues, identifying gene signatures and sex-specific modules associated with microglia activation and neuronal loss.
npj Aging · Jul 16, 2025Peer-reviewedNeuroscience