Benjamin P. Readhead

Development of a high-throughput, quantitative platform using human cerebral organoids to study virus-induced neuroinflammation in Alzheimer's disease

This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.

Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implication for microglia activation and sex differences

This paper uses an interpretable deep learning framework to analyze transcriptomic data from Alzheimer's disease brain tissues, identifying gene signatures and sex-specific modules associated with microglia activation and neuronal loss.

Upregulation of the Proto-Oncogene Src Kinase in Alzheimer's Disease: From Molecular Interactions to Therapeutic Potential

This study shows Src kinase is upregulated and phosphorylated in Alzheimer's disease, interacts with Tau, and may be a therapeutic target.

Reliable multiplex generation of pooled induced pluripotent stem cells for genetic testing

The paper introduces a method to multiplex reprogram somatic cells into iPSCs and estimates donor contributions using pooled sequencing and SNPs, finding consistent reprogramming ability across donors.

Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus MT:10398A>G

The paper investigates the association between mitochondrial variant MT:10398A>G and heteroplasmy in brain tissue and lymphoblastoid cell lines, identifying its role in mitochondrial function and disease phenotypes.

Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer's disease mouse model

This study shows that BCI-838, a mGluR2/3 antagonist, mimics exercise's benefits on neurogenesis, behavior, and molecular pathways in an Alzheimer's mouse model.

Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in In Vitro, In Vivo and Ex Vivo Models of Pulmonary Fibrosis

This study identifies saracatinib as a potential anti-fibrotic drug effective in multiple models of pulmonary fibrosis, showing equal or superior efficacy compared to existing treatments.

Deep Learning-Based Brain Transcriptomic Signatures Associated with the Neuropathological and Clinical Severity of Alzheimer's Disease

The paper uses deep learning to analyze RNA-seq data from Alzheimer's disease brain donors, identifying transcriptomic signatures linked to neuropathology and clinical severity.