Author

Simpson Joseph

University of California San DiegoORCID 0000-0002-0552-8221Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Boris RudolfsiD· 1 shared Cesar Arcasi Matta· 1 shared Chia Yi Yao· 1 shared Daniel B. HaackiD· 1 shared Frank V. MurphyiD· 1 shared Jason HingeyiD· 1 shared Navtej TooriD· 1 shared Scott A. StrobeliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

Boris RudolfsORCID

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3 papers

Recent·Most cited

Mapping RNA-Binding Proteins on the Ribosome by Tethered Micrococcal Nuclease

Chia Yi Yao, Simpson Joseph

The paper introduces TM-map, a method to map RNA-binding protein binding sites on RNA with high resolution, validated on bacteriophage MS2 coat protein and Drosophila FMRP.

Biochemistry · Jan 26, 2026Peer-reviewedBiochemistry

Protein Synthesis Profiling Enables In Vivo Capture of Ribosome-Associated mRNAs in Yeast

Cesar Arcasi Matta, Zhi Qi Ten, Simpson Joseph

This paper introduces PSP, a method to identify actively translated mRNAs in yeast without ribosome isolation, and shows it captures condition-specific translational programs and expands detectable genes.

bioRxiv · Nov 17, 2025 · PreprintBiochemistry

Structural evidence for metal ion catalysis in the ribosome

Jason Hingey, Boris Rudolfs, Daniel B. Haack, Scott A. Strobel, Frank V. Murphy, Simpson Joseph, Navtej Toor

The paper provides structural evidence for metal ion catalysis in peptide bond formation across ribosomes from bacteria, archaea, and eukaryotes.

bioRxiv · May 16, 2025 · PreprintBiochemistry