DJ-1 deficiency and aging: dual drivers of retinal mitochondrial dysfunction.
Mala Upadhyay, Johnathon Sturgis, Sanghamitra Bhattacharyya, Ke Jiang, Stephanie A. Hagstrom, Vera L. Bonilha
This study investigates how DJ-1 deficiency and aging jointly impact mitochondrial function in the retina and RPE, showing reduced OXPHOS complex levels and increased mtDNA damage.
bioRxiv · May 19, 2025 · PreprintNeuroscience