Author

Melike Sever

Hacettepe UniversityORCID 0000-0002-0592-9666Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 1

Frequent Co-Authors

Gökçe GürleriD· 2 shared Müge YemişçiiD· 2 shared Nevin BelderiD· 2 shared A. Semra Hız· 1 shared Alexandra DürriD· 1 shared Ayşe Miray OtoiD· 1 shared Christelle LéoniD· 1 shared Dilan Bozanoglu· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Gökçe GürlerORCID

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3 papers

Recent·Most cited

Characterization of a novel neurodevelopmental rare disease caused by a mutation within the autophagy gene ATG9B

Seval Kılıç, Kerem Esmen, Jean‐Loup Méreaux, Ayşe Miray Oto, Tansu Bilge Kose, Melike Sever, Emine Eren‐Koçak, Şeyda Demir, A. Semra Hız, Erum Afzal, Zahra Firoozfar, Gökhan Karakülah, H. Alper BAGRIYANIK, Léna Guillot‐Noël, Giulia Coarelli, , M. Kasim Diril

The paper reports a novel neurodevelopmental disorder caused by a frameshift mutation in ATG9B, and characterizes its effects using cell models and knock-in mice.

Genes · Jun 5, 2026Peer-reviewedGenetics

Reduced Folate Carrier 1 (RFC1/Slc19a1) Suppression Exacerbates Blood-Brain Barrier Breakdown in Experimental Ischemic Stroke in Adult Mice

Gökçe Gürler, Dilan Bozanoglu, Christelle Léon, Nevin Belder, Melike Sever, Radu I. Bolbos, Hülya Karataş, Marlène Wiart, Fabien Chauveau, Müge Yemişçi, Kadir Oguzhan Soylu

This study shows that reducing RFC1 worsens BBB breakdown and increases infarct size in a mouse model of ischemic stroke.

bioRxiv · Oct 28, 2024 · PreprintNeuroscience

REDUCED FOLATE CARRIER 1 IS PRESENT IN RETINAL MICROVESSELS AND CRUCIAL FOR THE INNER BLOOD RETINAL BARRIER INTEGRITY

Gökçe Gürler, Nevin Belder, Mustafa Çağlar Beker, Melike Sever, Gӧkhan Uruk, Ertuğrul Kılıç, Müge Yemişçi

This study shows RFC1 is present in retinal microvessels and regulates inner blood-retinal barrier integrity by affecting tight junction proteins and collagen-4.

bioRxiv · Oct 14, 2022 · PreprintNeuroscience