An iteratively curated CRISPR library reveals target-specific biological resistance landscapes across targeted protein degraders
Lin Liu, Olivia Voulgaris, Changqing Wang, Dáire Gannon, Matthew E. Ritchie, Rebecca Feltham, Stephin J. Vervoort
The paper develops a CRISPR library for TPD-compatible screens to better identify genetic interactions downstream of protein degradation by reducing UPS resistance dominance.
bioRxiv · Aug 21, 2026 · PreprintGenomics