Historical Contingency Shapes Toxin Resistance in a Specialist Avian Predator
Shabnam Mohammadi, S. Pradhan, Federico G. Hoffmann, Santiago Herrera‐Álvarez, Yuan Deng, Amy Eacock, Susanne Dobler, Jay F. Storz, Hannah M. Rowland
This study identifies molecular mechanisms of toxin resistance in black-headed grosbeaks through functional assays and ancestral protein resurrection, showing how historical contingency and epistasis shape adaptation.
bioRxiv · Jul 4, 2025 · PreprintEvolutionary Biology