Author

Santiago Herrera‐Álvarez

University of ChicagoORCID 0000-0002-0793-7811Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Amy EacockiD· 1 shared Federico G. HoffmanniD· 1 shared Hannah M. RowlandiD· 1 shared Jaeda E. J. PattoniD· 1 shared Jay F. StorziD· 1 shared Joseph W. ThorntoniD· 1 shared S. PradhaniD· 1 shared Shabnam MohammadiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperEvolutionary Biology

Amy EacockORCID

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2 papers

Recent·Most cited

The structure of an ancient genotype-phenotype map shaped the functional evolution of a protein family

Santiago Herrera‐Álvarez, Jaeda E. J. Patton, Joseph W. Thornton

The paper reconstructs ancestral transcription factors to study how ancient genotype-phenotype maps influenced the evolution of protein function.

Nature Ecology & Evolution · Jul 25, 2025Peer-reviewedEvolutionary Biology

Historical Contingency Shapes Toxin Resistance in a Specialist Avian Predator

Shabnam Mohammadi, S. Pradhan, Federico G. Hoffmann, Santiago Herrera‐Álvarez, Yuan Deng, Amy Eacock, Susanne Dobler, Jay F. Storz, Hannah M. Rowland

This study identifies molecular mechanisms of toxin resistance in black-headed grosbeaks through functional assays and ancestral protein resurrection, showing how historical contingency and epistasis shape adaptation.

bioRxiv · Jul 4, 2025 · PreprintEvolutionary Biology