Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury
Lilija Wehling, Liam Keegan, Paula Fernández‐Palanca, Reham A. R. A. Hassan, Ahmed Ghallab, Jennifer Schmitt, Yingyue Tang, Maxime Le Marois, Stephanie K. Roessler, Peter Schirmacher, Ursula Kummer, Jan Georg Hengstler, Sven Sahle, Kai Breuhahn
The paper uses PDE modeling and image analysis to show that nuclear phosphorylation and AKT interaction regulate YAP and TAZ shuttling dynamics in response to APAP-induced liver injury.
eLife · Sep 22, 2022Peer-reviewedMolecular Biology