Stephanie K. Roessler

This study identifies genetic vulnerabilities from chromosome loss events in cancer by analyzing CRISPR screening data and copy number profiles, revealing paralogous gene dependencies as therapeutic targets.

This study identifies epithelial state transitions driven by inflammation that promote tumorigenesis, showing that targeting NOTCH signaling can prevent pre-neoplastic to neoplastic transition.

The paper uses PDE modeling and image analysis to show that nuclear phosphorylation and AKT interaction regulate YAP and TAZ shuttling dynamics in response to APAP-induced liver injury.