Author

Thomas J. Krzystek

ALS Therapy Development InstituteORCID 0000-0002-0692-0241Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Anushka Bhargava· 1 shared Fernando G. VieiraiD· 1 shared Kyle R. Denton· 1 shared Nguyen PT Huynh· 1 shared Swetha Gurumurthy· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperNeuroscience

Anushka Bhargava

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1 paper

Recent·Most cited

Generation and validation of a human iPSC-derived TDP-43 knockout model for ALS disease modeling.

Swetha Gurumurthy, Anushka Bhargava, Nguyen PT Huynh, Thomas J. Krzystek, Fernando G. Vieira, Kyle R. Denton

The paper generates and validates a human iPSC-derived TDP-43 knockout model for ALS, showing widespread cryptic exon inclusion and identifying potential therapeutic modulators.

bioRxiv · May 2, 2026 · PreprintNeuroscience