Modular Scaffold Crystals for Programmable Installation and Structural Observation of DNA-Binding Proteins
Ethan T. Shields, Caroline K. Slaughter, Fadwa Mekkaoui, Emma N. Magna, Cole Shepherd, Philip S. Lukeman, Donald E. Spratt, Christopher Davis Snow
This paper develops modular DNA scaffold crystals for programmable installation and structural observation of DNA-binding proteins, enabling high-throughput structure determination and functional applications.
bioRxiv · Mar 6, 2026 · PreprintBioengineering