Christopher Davis Snow

Live-cell, single-molecule imaging resolves the dual nature of mRNA silencing by SARS-CoV-2 Nsp1

This study uses live-cell imaging to show SARS-CoV-2 Nsp1 silences mRNAs by reducing their numbers through two cap-dependent mechanisms, while viral UTRs enhance translation but do not protect from Nsp1.

UTag, a cysteine-free thermostable tagging system for tracking single mRNA translation live

The paper develops a cysteine-free UTag system for live-cell single-mRNA translation tracking, showing improved thermostability and performance comparable to existing systems.

Modular Scaffold Crystals for Programmable Installation and Structural Observation of DNA-Binding Proteins

This paper develops modular DNA scaffold crystals for programmable installation and structural observation of DNA-binding proteins, enabling high-throughput structure determination and functional applications.

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications

This paper presents an AI-driven method to convert antibody sequences into functional intrabodies, successfully converting 19 out of 26 sequences, including those targeting histone modifications.

Democratizing Protein Language Model Training, Sharing and Collaboration

The paper introduces SaprotHub, a platform that simplifies training and sharing of protein language models, enabling non-experts to build and collaborate on customized models.

PAbFold: Linear Antibody Epitope Prediction using AlphaFold2

PAbFold predicts linear antibody epitopes using AlphaFold2 by modeling antibody-antigen complexes, showing accuracy on known targets and validating on a novel anti-SARS-CoV-2 antibody.