Inhibition of Na/H exchanger-1 in the right ventricle and lung dysfunction induced by experimental pulmonary arterial hypertension in rats
Giuseppina Milano, Melanie Reinero, Julien Puyal, Piergiorgio Tozzi, Michele Samaja, Florence Porte, Maurice Beghetti
This study shows that inhibiting NHE-1 with rimeporide reduces right ventricular hypertrophy, pulmonary vascular remodelling, inflammation, and fibrosis in a rat model of pulmonary arterial hypertension.
Journal of the American Heart Association · Mar 7, 2025Peer-reviewedPhysiology