An IGF2-anchored oncofetal state and relapse-associated transcriptomic module define systemic progression risk in early-onset colorectal cancer
Elena Licitra-Rosa, Giulia Mantini, Federica Persiani, Eleonora Ponterio, Sebastiano Di Bella, Laura Lorenzon, Giulia Scaglione, Miriam Caimano, Domenico D’Ugo, Lisa Salvatore, Maria Alessandra Calegari, Gianfranco Zannoni, Giorgio Stassi, Ruggero De Maria
This paper identifies an IGF2-driven oncofetal state and a 5-gene module that predict systemic relapse in early-onset colorectal cancer, improving risk stratification beyond traditional staging.
bioRxiv · May 20, 2026 · PreprintCancer Biology