Complementation between pathological prion protein subassemblies to cross existing species barriers
Angélique Igel‐Egalon, Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Laëtitia Herzog, Fabienne Reine, Juan María Torres, Hubert Laude, Human Rézaei, Vincent Béringue
The paper shows that structurally diverse PrPSc assemblies complement each other to cross species barriers, supporting the quasi-species concept in prions.
bioRxiv · Dec 3, 2019 · PreprintNeuroscience