Author

Hyun Yi Kook

Chonnam National UniversityORCID 0000-0002-0740-1806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Joo‐Young KangiD· 2 shared Sang‐Beom SeoiD· 2 shared Anna Jeong· 1 shared Dae‐Hwan KimiD· 1 shared Duk‐Hwa KwoniD· 1 shared Gaeun KangiD· 1 shared Gwang Hyeon EomiD· 1 shared Hana ChoiD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersDevelopmental Biology

Joo‐Young KangORCID

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3 papers

Recent·Most cited

SRF is a non-histone methylation target of KDM2B and SET7 in the regulation of myogenesis

Hosouk Joung, Joo‐Young Kang, Jiyoung Kim, Duk‐Hwa Kwon, Anna Jeong, Hyun-Ki Min, Sera Shin, Yun-Gyeong Lee, Young‐Kook Kim, Sang‐Beom Seo, Hyun Yi Kook

This study identifies SRF as a non-histone target of KDM2B and SET7, showing their role in regulating muscle differentiation through methylation of SRF K165.

bioRxiv · Apr 17, 2020 · PreprintDevelopmental Biology

Cardiac nitric oxide synthase 1 worsens heart failure with preserved ejection fraction through S-nitrosylation of histone deacetylase 2

Somy Yoon, Mi‐Ra Kim, HanGyeol Lee, Gaeun Kang, Kwang Il Nam, Hyun Yi Kook, Gwang Hyeon Eom

This study shows that nNOS-induced S-nitrosylation of HDAC2 worsens HFpEF, suggesting new therapeutic targets and explaining the ineffectiveness of NO-enhancing therapies.

bioRxiv · Jul 22, 2019 · PreprintMolecular Biology

KDM2B is a histone H3K79 demethylase and induces transcriptional repression via SIRT1-mediated chromatin silencing

Joo‐Young Kang, Ji‐Young Kim, Kee‐Beom Kim, Jin Woo Park, Hana Cho, Ja Young Hahm, Yun‐Cheol Chae, Dae‐Hwan Kim, Hyun Yi Kook, Sangmyeong Rhee, Nam‐Chul Ha, Sang‐Beom Seo

This study identifies KDM2B as an H3K79 demethylase that represses transcription by promoting SIRT1-mediated chromatin silencing.

The FASEB Journal · May 15, 2018Peer-reviewedGenetics