Cardiac nitric oxide synthase 1 worsens heart failure with preserved ejection fraction through S-nitrosylation of histone deacetylase 2
Somy Yoon, Mi‐Ra Kim, HanGyeol Lee, Gaeun Kang, Kwang Il Nam, Hyun Yi Kook, Gwang Hyeon Eom
This study shows that nNOS-induced S-nitrosylation of HDAC2 worsens HFpEF, suggesting new therapeutic targets and explaining the ineffectiveness of NO-enhancing therapies.
bioRxiv · Jul 22, 2019 · PreprintMolecular Biology