Peptide-RNA photocrosslinks with tunable RNA chain map RNA interfaces proteome-wide
Shuyao Sha, Bernhard Küster, Jakob Trendel
The paper introduces pepR-MS and SALT to map protein-RNA interfaces at single-amino acid and nucleotide resolution, identifying over 34,000 crosslinks in breast cancer cells.
bioRxiv · Sep 5, 2025 · PreprintMolecular Biology