Jakob Trendel

This paper introduces a method using high-intensity longwave UV light to rapidly perform in-cell photo-crosslinking with minimal photodamage, enabling fast analysis of biomolecular interactions.

The paper introduces pepR-MS and SALT to map protein-RNA interfaces at single-amino acid and nucleotide resolution, identifying over 34,000 crosslinks in breast cancer cells.

The paper quantifies proteins directly interacting with DNA in human cells and identifies key transcription factors and DNA damage proteins in response to treatments.

The paper introduces XRNAX, a method to purify protein-RNA complexes, and shows it captures all RNA biotypes and reveals dynamic changes in the RNA-bound proteome during arsenite-induced stress.