Molecular BiologyCell ReportsPeer-reviewed
Polymer physics and machine learning reveal a combinatorial code linking chromatin 3D architecture to 1D epigenetics
Andrea Esposito, Simona Bianco, Andrea M. Chiariello…·Mario Nicodemi
The paper uses machine learning and polymer physics to infer 3D chromatin architecture from Hi-C data and shows how 1D epigenetic patterns encode this structure through combinatorial binding site arrangements.