Andrea M. Chiariello

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

The paper uses polymer physics models and simulations to show how chimeric proteins cause aberrant chromatin looping, and proposes strategies to inhibit this process.

The paper shows that genome-lamina interactions are reconfigured during limb development to prime regulatory domains for gene activation and support cell-fate decisions.

This study shows that a single cocaine exposure causes long-lasting 3D genome structure changes in midbrain dopamine neurons, affecting gene regulation and synaptic plasticity.

The paper investigates how ecDNA clusters form through phase separation, creating regulatory contacts that boost MYC expression, and shows how JQ1 disrupts this process.

The paper introduces multiplex-GAM, a ligation-free method for genome-wide chromatin contact mapping, showing it detects different strong contacts compared to Hi-C, particularly involving active genomic regions.

The paper compares loop-extrusion and polymer phase-separation models against chromatin data, finding they can co-exist in shaping single-cell chromatin architecture.

The paper uses machine learning and polymer physics to infer 3D chromatin architecture from Hi-C data and shows how 1D epigenetic patterns encode this structure through combinatorial binding site arrangements.

The paper shows that divergent gene expression within TADs is resolved through TAD restructuring and DNA methylation, not enhancer-promoter compatibility or position.

This study investigates how CTCF binding sites mediate transcriptional insulation in mouse embryonic stem cells, showing that insulation depends on CTCF site number, sequence context, and TAD boundary location.

The paper uses polymer physics models to show that chromatin folding variability in single cells arises from phase separation driven by chromatin factor interactions.

The paper investigates cell-type specific 3D chromatin structures in the brain using immunoGAM, finding TAD melting, neuron-specific contacts, and compartmentalization patterns related to gene expression and neurodegenerative diseases.

The paper shows that preformed chromatin topology supports robust Shh transcription during limb development, with CTCF and ZRS alleles influencing enhancer-promoter communication.

The paper develops Tri-C, a single-cell 3C method, to reveal dynamic chromatin interactions and regulatory hubs in mammalian cells.

The paper investigates how promoter activation states influence the 3D folding of the HoxB locus in mouse ES cells using simulations and single-cell imaging.