Induction Of Chronic Stress Reveals An Interplay Of Stress Granules And TDP-43 Pathological Aggregates In Human ALS Fibroblasts And iPSC-Neurons
Antonia Ratti, Valentina Gumina, Paola Lenzi, Patrizia Bossolasco, Federica Fulceri, Clara Volpe, Donatella Bardelli, Francesca Pregnolato, AnnaMaria Maraschi, Francesco Fornai, Vincenzo Silani, Claudia Colombrita
This study shows chronic oxidative stress induces stress granules and TDP-43 aggregates in ALS patient cells, linking SG dysfunction to TDP-43 pathology.
Neurobiology of Disease · Aug 20, 2020Peer-reviewedNeuroscience