Patrizia Bossolasco

This study shows tumor-associated macrophages promote tumor innervation and spinal cord repair through neural growth and mTORC2 signaling.

This study investigates how NEK1 haploinsufficiency affects C9ORF72 pathology in patient-derived iPSC-motoneurons, finding increased DNA damage but no additional ciliogenesis defects.

This study shows that NEK1 haploinsufficiency in human iPSC-derived motoneurons and brain organoids impairs ciliogenesis, linking NEK1 mutations to ALS through reduced primary cilium formation.

This study shows chronic oxidative stress induces stress granules and TDP-43 aggregates in ALS patient cells, linking SG dysfunction to TDP-43 pathology.