Author

Zonghui Li

Zhejiang University of TechnologyORCID 0000-0002-0772-1738Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Guijun ZhangiD· 2 shared Jian ZhuangiD· 1 shared Ren‐Chao ZhengiD· 1 shared Suhui WangiD· 1 shared Zexin Lv· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersBioinformatics

Guijun ZhangORCID

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2 papers

Recent·Most cited

ForceFlowAb: physics-aware mixture-of-experts flow matching model for antibody CDRs design

Zonghui Li, Zexin Lv, Guijun Zhang

ForceFlowAb improves antibody CDR design by combining adaptive routing and physics-based guidance, achieving better interaction energies than existing methods.

bioRxiv · Sep 14, 2026 · PreprintBioinformatics

Sequence-aware Prediction of Point Mutation-induced Effects on Protein-Protein Binding Affinity using Deep Learning

Jian Zhuang, Zonghui Li, Suhui Wang, Ren‐Chao Zheng, Guijun Zhang

SAMAffinity predicts mutation-induced changes in protein-protein binding affinity using a sequence-aware deep learning model, outperforming existing methods on multiple datasets.

bioRxiv · Nov 15, 2025 · PreprintBioinformatics