Jian Zhuang

SAMAffinity predicts mutation-induced changes in protein-protein binding affinity using a sequence-aware deep learning model, outperforming existing methods on multiple datasets.

DeepAAAssembly improves antibody-antigen complex modeling by integrating dynamic interactions, outperforming AlphaFold3 on a benchmark set.

MultiSAAI predicts antibody-antigen interactions using a multi-scale deep learning framework, achieving high AUROC scores on benchmark datasets.

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.

The paper identifies a novel GATA4 variant associated with familial atrial septal defect through genetic analysis and functional assays.