Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering
Karin R. Purshouse, Elias T. Friman, Shelagh Boyle, Pooran Singh Dewari, Vivien Grant, Alhafidz Hamdan, Gillian M. Morrison, Paul Martin Brennan, Sjoerd Viktor Beentjes, Steven M. Pollard, Wendy A. Bickmore
The paper investigates oncogene expression from extrachromosomal DNA in glioblastoma and finds that copy number amplification, not spatial clustering, drives high transcriptional output.
eLife · Oct 28, 2022Peer-reviewedGenetics