Paul Martin Brennan

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

The paper uses single cell proteomic analysis to identify distinct functional states of neutrophils in human glioblastoma, revealing clusters with pathogenic and anti-tumorigenic properties not detectable by scRNA-seq.

FMRP regulates adult human cortical neuron excitability via cyclic-AMP signalling

This study shows that FMRP depletion in human neurons causes cyclic-AMP-dependent hyperexcitability, which can be corrected by inhibiting phosphodiesterase 4D.

Absence of short-term axon initial segment plasticity in human, mouse, and rat cortical circuits

The paper tests for axon initial segment (AIS) structural plasticity in human, mouse, and rat cortical neurons across different conditions and finds no evidence of AIS length changes over short-term activity modulation.

Spatial dynamics of IFITM1: a core component of the interferon-stimulated gene-resistance signature in glioma

This study investigates the spatial dynamics of IFITM1 in glioma, showing context-dependent localization and interactions with IFITM3, suggesting potential therapeutic targets.

Opposing roles of physiological and pathological amyloid-β on synapses in live human brain slice cultures

This study uses live human brain slice cultures to show that physiological and pathological amyloid-beta have opposing effects on synapses, with physiological levels enhancing synaptic transcripts and pathological levels causing synaptic loss.

Systematic identification of context-dependent gene essentiality in Glioblastoma: The GBM-CoDE platform

The paper identifies context-dependent gene essentiality in GBM using CRISPR screening and develops a platform to link biomarkers to therapeutic targets.

Phylogenetic divergence of GABAB receptor signalling in neocortical networks over adult life.

This study quantifies how GABAB receptor signalling contributes to circuit-level inhibition in rat and human cortical principal cells across the lifespan, revealing age and species differences.

Tau phosphorylated at serine 356 is associated with Alzheimer's disease pathology and can be lowered in mouse and human brain tissue using the NUAK inhibitor WZ4003

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

The paper shows human astrocytes and microglia ingest more synapses in Alzheimer's disease via MFG-E8, and inhibiting MFG-E8 reduces this ingestion in cultured cells.

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering

The paper investigates oncogene expression from extrachromosomal DNA in glioblastoma and finds that copy number amplification, not spatial clustering, drives high transcriptional output.

The immunopeptidome from a genomic perspective: Establishing immune-relevant regions for cancer vaccine design

The paper develops COD-dipp to map MHC Class I antigens from cancer studies and identifies immune-relevant genomic regions for vaccine design.

Nanopore sequencing enables comprehensive transposable element epigenomic profiling

This study uses nanopore sequencing and the TLDR tool to profile CpG methylation of transposable elements in human tissues and tumors.

Whole genome sequencing for diagnosis of neurological repeat expansion disorders

This study demonstrates that whole genome sequencing can effectively detect repeat expansions in neurological disorders with high sensitivity and specificity, enabling diagnosis in previously undiagnosed patients.