Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice
Yunting Wang, Alexandra K. Moura, Rui Min Zuo, Wei Zhou, Zhengchao Wang, Kiana Roudbari, Jenny Z. Hu, Pin‐Lan Li, Yang Zhang, Xiang Li
This study shows that hypercholesterolemia causes coronary microvascular dysfunction in mice through enhanced lysosomal signaling in endothelial cells, which can be mitigated by ezetimibe.
Journal of the American Heart Association · Nov 27, 2024Peer-reviewedPharmacology & Toxicology