Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression
Michael Nshanian, Joshua James Gruber, Benjamin S. Geller, Faye Chleilat, Samuel M. Lancaster, Shannon M. White, L. А. Alexandrova, Jeannie M. Camarillo, Neil L. Kelleher, Yingming Zhao, Michael P. Snyder
This study maps the genome-wide binding of propionate and butyrate as acyl histone marks and shows their role in gene regulation and cell function.
Nature Metabolism · Jan 9, 2025Peer-reviewedGenetics