Samuel M. Lancaster

Polyclonal origins of human premalignant colorectal lesions

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression

This study maps the genome-wide binding of propionate and butyrate as acyl histone marks and shows their role in gene regulation and cell function.

Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program

The paper examines microbiome and immune changes in depression during a psychosocial intervention, finding a protective role for Prevotella-dominant microbiomes and reduced inflammation.

Fitness benefits of loss of heterozygosity in Saccharomyces hybrids

This study identifies beneficial alleles lost through LOH in yeast hybrids, showing how LOH can drive adaptation to new environments.