Joshua James Gruber

The paper measures histone synthesis rates in vivo and finds that stress induces a surge in hepatocyte nucleosome production uncoupled from DNA replication.

This study maps the genome-wide binding of propionate and butyrate as acyl histone marks and shows their role in gene regulation and cell function.

This study identifies a four amino acid motif in VISTA that suppresses tumor growth by altering EGFR signaling through NUMB recruitment.

This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.

This paper identifies HAT1 as a gene that links nutrient metabolism to histone production through a gene-metabolite circuit, showing its role in cell proliferation and its association with cancer outcomes.