The Impact of Methylglyoxal and SOD1 Mutation on TDP-43 Interaction in ALS Proteinopathy
Gabriela Delaqua Ribeiro, Daniela Dias Queiroz, José Raphael Monteiro Neto, Gabriel Freitas de Souza, Paola Albino, Luan H. Paranhos, Tiago F. Outeiro, Elis C. A. Eleuthério
This study investigates how methylglyoxal and G93A SOD1 mutation affect TDP-43 interaction, showing increased cytosolic TDP-43 aggregation and reduced cell viability.
bioRxiv · Sep 25, 2025 · PreprintCell Biology