A transient third metal ion shapes the catalytic cycle of a group I intron ribozyme
Erika McCarthy, Şölen Ekesan, Timothy J. Giese, Yanan Du, German Patricio Barletta, Andreas W. Götz, Joseph A. Piccirilli, Darrin M. York
This paper investigates the role of a third metal ion in the catalytic cycle of a group I intron ribozyme using computational methods and proposes design modifications to expand its sequence compatibility.
bioRxiv · Oct 9, 2026 · PreprintBiophysics