NGAL drives cardiac dysfunction and fibrosis in rats with chronic kidney disease
Matthieu Soulié, Tania Sánchez‐Bayuela, Ixchel Lima‐Posada, Yohan Stephan, Lionel Nicol, Zohra Lamiral, Jérémy Lagrange, Adriaan A. Voors, Natalia López‐Andrés, Nicolas Girerd, Paul G.H. Mulder, Frédéric Jaisser
This study shows that NGAL contributes to cardiac dysfunction and fibrosis in CKD rats through a Gal-3/Tlr4 pathway, with implications for human HFpEF.
bioRxiv · Aug 27, 2025 · PreprintPathology