Natalia López‐Andrés

This study shows glycolysis and the hexosamine biosynthesis pathway are essential for inflammatory protein maturation and leukocyte adhesion in aortic valve cells during calcific aortic valve disease.

This study identifies a novel signaling pathway involving MR, NGAL, and TLR4 that drives aortic valve remodeling in chronic kidney disease.

This study shows that NGAL contributes to cardiac dysfunction and fibrosis in CKD rats through a Gal-3/Tlr4 pathway, with implications for human HFpEF.

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.