Cocaine exacerbates neurological impairments and neuropathologies in the iTat model of HIV-associated neurocognitive disorder through genome-wide alterations of DNA methylation and gene expression
Xiaojie Zhao, Fan Zhang, Suresh R. Kandel, Frédéric Brau, Johnny J. He
This study shows that cocaine worsens HAND symptoms in an HIV mouse model by altering DNA methylation and gene expression, affecting neuronal and glial functions.
bioRxiv · Nov 22, 2021 · PreprintGenomics