Fan Zhang

The paper introduces BioScientist Agent, a framework combining a biomedical knowledge graph, variational graph auto-encoder, reinforcement learning, and LLMs to improve drug repurposing and mechanistic reasoning.

This study shows that cocaine worsens HAND symptoms in an HIV mouse model by altering DNA methylation and gene expression, affecting neuronal and glial functions.

This study reclassifies tumors based on drug response and genomic alterations, revealing molecular concordance in therapy across histologically different cancers.