Multiscale modeling of blood circulation with cerebral autoregulation and network pathway analysis for hemodynamic redistribution in the vascular network with anatomical variations and stenosis conditions
Jiawei Liu, Atsushi Kanoke, Hidenori Endo, Kuniyasu Niizuma, Hiroshi Suito
This study develops a multiscale circulation model of cerebral hemodynamics to simulate flow redistribution in the Circle of Willis under normal, anatomical variation, and stenosis conditions, revealing key collateral pathway activation patterns.
PLoS Computational Biology · May 18, 2026Peer-reviewedBiophysics